PAGE2019-Satellite-Workshop:

Reproducible Pharmacometrics 2.0: Generation of submission-ready Word reports based on open source tools

PAGE 2019 Meeting, June 10 Monday, 13:00-17:00
Mindset Konferens, Room: Ettan, Mäster Samuelsgatan 60, Stockholm [View Map]

Workshop Description

Pharmacometric reports typically contain a large number of figures, tables, text files, in-line text, and numerical values that have been generated during the conduct of analyses. While these results are often generated in a script-based manner, reporting of these results is complicated by corporate requirements to use Microsoft Word and a specific in house-style guide, requiring scientists to copy, paste, and format results manually in a time-consuming and error-prone process.

Wilkins and Jonsson [Reproducible pharmacometrics, PAGE Meeting, Glasgow, Scotland, 2013] presented an approach to Reproducible Pharmacometrics that allowed a full end-to-end scripting of the analysis and the creation of publication-ready reports. Their solution was based on LaTeX, knitr, and R. While this approach is very powerful, LaTeX can be perceived as a cumbersome language. More importantly, the output is a PDF rather than a Word document, which often does not comply with corporate publication policy. In recent years, R Markdown has been developed, allowing to use the more lightweight language Markdown, and RStudio supporting the conversion to Word. However, no R Markdown support is available for critical Word features, such as cross-references, figure and table captions, and choice of more complex Word styles, impeding the generation of submission-ready Word documents.

In this workshop, participants will first get familiar with R Markdown and its limitations to produce submission-ready Word reports. We will then introduce Extended Markdown language and present the framework on how one would leverage open-source tools to overcome those shortcomings. Using IntiQuan IQReport, a standalone software that implements the presented approach, participants will engage in the hands-on experience of creating Word reports using any desired/template Word style and automatically integrating analysis results without the need of manual copy & paste. Free license for IQReport with the duration of 12 months will be provided on request to all interested participants.

The workshop is designed as a hands-on tutorial, allowing participants to work through all examples under guidance of the presenters. All material (slides, example reports, R code, required R libraries, and additional software) will be shared with the participants at least 2 weeks before the workshop. In case a participant would like to have hands-on experience during the workshop, a laptop (preferably Windows) with an R installation should be brought to the workshop.

Workshop location:

Room ETTAN
Mindset Konferens
Mäster Samuelsgatan 60
Stockholm
[View Map]

Registration

The regular workshop fee is 250 EUR for industry, 150 EUR for academia/government/non-profit, and 100 EUR for students. This includes workshop material and coffee break. Payment can be done conveniently and securely via PayPal, here below:

Please select the rate that applies to you based on your affiliation (right hand side). Then, by clicking the “Pay Now” button you are redirected to PayPal, allowing secure payment of the workshop fee. An invoice will be sent to you by email. We send out this invoice manually, so please give us a minute to do that.Refund policy: No refunds.

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Program

June 10th Monday
Time Topic Presenter
12:00-13:00 Lunch will be provided for participants that take part in both the QSP modeling and the reporting workshop
13:00-13:15 Welcome and Introduction Henning Schmidt 
13:15-14:00
  • General approach to automatic reporting and underlying tools used
  • Report elements that are critical for typical pharmacometric reports
  • Advantages and disadvantages of alternative approaches (Rmarkdown, knitr, LaTeX)
  • Markdown and Extended Markdown
Henning Schmidt 
14:00-15:00
  • Generation of a simple example Word report
  • Import of text files (e.g. NONMEM control/output files) into Word
  • Import of figures in different formats into Word
  • Import of R / MATLAB / etc. data frames and matrices as tables into Word
Henning Schmidt 
15:00-15:15 Coffee break
15:15-16:00
  • Advanced formatting of figures and tables through Extended Markdown
  • Cross references
  • Introduction of Value Tables, allowing in-line adding of analysis results
  • Annotating imported WORD tables, figures, and text files with trace-ability information
  • Generation of a full popPK example report
Henning Schmidt 
16:00-16:45
  • Adjusting the report Word style to a specific corporate style
  • Script based generation of a full report from R
Henning Schmidt 
16:45-17:00 Concluding remarks Henning Schmidt