PAGE2019-Satellite-Workshop:

QSP modeling in R

PAGE 2019 Meeting, June 10 Monday, 08:00-12:00
Mindset Konferens, Room: Ettan, Mäster Samuelsgatan 60, Stockholm [View Map]

Workshop Description

IntiQuan is running a half-day hands-on workshop on QSP modeling, simulation, and parameter estimation in R. The major topics covered are:

  • QSP modeling in R. Description of models and simulation
  • Reuse of models from model databases – import of SBML models to R
  • Introduction to a realistic QSP modeling example
  • Robust parameter estimation based on sensitivity equations and multi-start optimization in R
  • Analyzing models, informing modeling decisions, using profile likelihood

After the workshop, the participants will be able to write mechanistic QSP models, simulate them, graphically explore their data, and perform parameter estimation using the functionality provided by IQR Tools.

The workshop is designed as a hands-on tutorial. Each topic will first be presented on slides and will be illustrated based on a realistic QSP example. Then, the participants will have the chance to implement and reproduce the different modeling steps on their own resorting on a provided example model that is suitable for the workshop. IntiQuan personnel will be around at all time to support the participants.

Participants are supposed to bring their laptops. Ideally, R and IQR Tools should be installed before the workshop. Participants will receive installation instructions before the workshop and are encouraged to contact the presenters for support to setup IQR Tools on their system. Note that administrator rights are needed for some parts such that installation during the workshop might not be possible.

Basic knowledge of writing scripts in R is of advantage.

Workshop location:

Room ETTAN
Mindset Konferens
Mäster Samuelsgatan 60
Stockholm
[View Map]

Registration

The regular workshop fee is 250 EUR for industry, 150 EUR for academia/government/non-profit, and 100 EUR for students. This includes workshop material and coffee break. Payment can be done conveniently and securely via PayPal, here below:

Please select the rate that applies to you based on your affiliation (right hand side). Then, by clicking the “Pay Now” button you are redirected to PayPal, allowing secure payment of the workshop fee. An invoice will be sent to you by email. We send out this invoice manually, so please give us a minute to do that.Refund policy: No refunds.

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Select the rate that applies to you:



Program

June 10th Monday
Time Topic Presenter
08:00-08:15 Welcome and Introduction Daniel Kaschek
08:15-10:00
  • Set-up and simulation of mechanistic QSP models.
  • Reuse of models from model databases – import of SBML models.
  • Model-supported exploration of data
  • Linking data and model: parameter estimation with IQR Tools
 Daniel Kaschek
10:00-10:15 Coffee break
10:15-12:00
  • Multi-start optimization and exploration of the parameter space.
  • Uncertainty analysis using the profile likelihood method.
 Daniel Kaschek
12:00-13:00 Lunch will be provided for participants that take part in both the QSP modeling and the reporting workshop