Increased demand for model-based pharmacometric and systems pharmacology analyses requires user-friendliness, flexibility, efficiency, compliance, and state-of-the-art methodology. IQR Tools enables seamless access to pharmacometrics parameter estimation tools, such as NONMEM, MONOLIX, and NLMIXR. In addition, it provides a world-leading powerful estimation method for systems pharmacology type of modeling. Important other features are the seamless integration of optimal experiment design and NCA functionality.