Increased demand for support of model-based pharmacometric and systems pharmacology analyses requires tools that meet requirements regarding user-friendliness, flexibility, efficiency, compliance, and state of the art methodology. However, there is arguably no current single tool that fulfills all these requirements.
IQRtools has been developed as a software package for the well-established and free statistical software environment R. Guiding principles for the implementation have been user-friendliness, flexibility, extensibility, and compliance.
IQRtools enables a seamless access to available pharmacometric parameter estimation tools, such as NONMEM, MONOLIX, and NLMIXR. In addition it provides a very stable and powerful estimation method for systems pharmacology type of modeling. It further enables a straight forward transition from mechanistic systems pharmacology to descriptive pharmacometric models, efficiently supports reproducibility and compliance, and supports automatic reporting of results in Microsoft Word.