Leverage SBML models for modeling in Quantitative Systems Pharmacology


Systems Pharmacology gains in interest in the Modeling and Simulation community. Thus does also the Systems Biology Markup Language (SBML), in which many systems pharmacology type of models are coded (see, e.g. Biomodels Database).

SBML, however, is very badly supported when using R. Some packages (such as SBMLR) are available and claim to be able to import and simulate SBML models. However, typically, not all features of SBML models are considered.

The IQRsbml software from IntiQuan allows to convert SBML models to a humanly readable ODE and/or biochemical reaction based format. This format is very close to Berkeley Madonna and can easily be post-processed to get it into NONMEM or MONOLIX.

The future R based IntiQuan tools will be able to import SBML models directly via the IQRsbml software, which needs to be installed separately.

  • IQRsbml is provided free of charge
  • Get IQRsbml from here